Melatonin Receptor 1B Polymorphisms and Reproductive Failure – a Pilot Study
نویسندگان
چکیده
The present study aimed to investigate the possible associations between melatonin receptor 1B (MTNR1b) genetic polymorphisms and presence of reproductive disturbances due spontaneous abortion implantation failure leading pregnancy loss. patients group included 35 women presenting with one or more miscarriages and/or failure. Another 36 healthy without history at least birth served as a control group. Genomic DNA was extracted genotyping for MTNR1b rs1562444, rs10830962 rs10830963 performed by PCR-RFLP analysis. genotype distribution investigated in did not differ significantly (p > 0.05 all). Nevertheless, haplotype rs1562444 AA GG less common than (2.9% vs. 22.2%, p = 0.028). We suggest that might be protective against miscarriage. Additionally, found recurrent Studies larger populations are necessary reveal proper different haplotypes, ovarian function
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ژورنال
عنوان ژورنال: Dokladi na B?lgarskata akademiâ na naukite
سال: 2022
ISSN: ['2367-5535', '1310-1331']
DOI: https://doi.org/10.7546/crabs.2022.05.15